What is a commonly prescribed thiazide diuretic?

Hydrochlorothiazide is a commonly prescribed thiazide diuretic because it effectively promotes the excretion of sodium and water through the kidneys, helping to reduce blood volume and, subsequently, blood pressure. Thiazide diuretics are often used as a first-line treatment for hypertension due to their efficacy and relatively favorable side effect profile. They work by inhibiting sodium reabsorption in the distal convoluted tubules of the nephron, leading to increased urine output.

The other medications listed have different classifications and uses. Spironolactone is a potassium-sparing diuretic, primarily used for conditions like heart failure and edema. Amlodipine is a calcium channel blocker used to lower blood pressure, but it is not a diuretic. Losartan is an angiotensin II receptor antagonist used to treat hypertension but also does not function as a diuretic. Therefore, when considering thiazide diuretics specifically, hydrochlorothiazide is clearly the correct answer.