Which class of antihypertensive drugs should be avoided during pregnancy?

The class of antihypertensive drugs that should be avoided during pregnancy includes ACE inhibitors and Angiotensin II Receptor Blockers (ARBs) due to their potential teratogenic effects. These medications are known to cause significant harm to the developing fetus, particularly during the second and third trimesters. They can lead to serious complications such as renal impairment, oligohydramnios (low amniotic fluid), and can adversely affect fetal cardiovascular function.

In contrast, while beta-blockers and calcium channel blockers may have certain risks, they are sometimes used when necessary in pregnant individuals with hypertension. Thiazide diuretics are also generally considered safer than ACE inhibitors and ARBs but are often avoided unless absolutely necessary as they can decrease placental perfusion if high doses are used.

The safety profile of ACE inhibitors and ARBs is well-documented, and their contraindication in pregnancy is a critical consideration in managing hypertensive patients who are pregnant, making this the correct choice.